Role of BRAF V600E Mutation in Papillary Thyroid Cancer

Talking about thyroid carcinomas leaves a fairly wide slope, in which it should be considered not only the variants and their clinical frequency, but mutant genetic finding that gives preamble to malignancy, its variability, histological as well prognosis. It is important note most frequent carcinoma population papillary, with an index greater than 80% of all cases, being rare pediatrics. The papillary subtype result one two possible alterations affecting genes encoding tyrosine kinase, either RET gene chromosome 10q11 or BRAF gene, by early mutation MAP kinase signaling pathway. Statistically, known represents give rise carcinoma, turn, this presents alteration amino acid 600, 600E gene. That why, research work focuses on role V600E from pathogenic mechanism mutation, location mutation. Clinical histopathological relationship prognosis certain related complications are mentioned.